Click the "Select File" button above, and choose your TSZ file.
You’ll see a preview, if available.
Click the "Convert file to..." button to extract text information.
Convert TSZ to another file type
To convert your TSZ file to another format, you need tskit & Topcon TSwin or other Data software.
Convert a file to TSZ
To convert other file formats to the "Genomics & Ophthalmic Data" file type, you need software like tskit & Topcon TSwin or a similar tool.
About TSZ files
The .tsz file extension represents two distinct, highly technical data formats used in completely different industries. Most commonly in modern research, it indicates a Tree Sequence Zip file, a compressed format used by the tskit Python library to store large-scale genetic ancestry and evolutionary data. These files are essentially .trees files compressed (often using gzip) to save space while retaining complex genealogical histories. Users often need to convert these to VCF (Variant Call Format) or export tables to CSV for analysis in Excel or R.
Alternatively, in the medical field, a .tsz file is a proprietary measurement or calibration file generated by Topcon ophthalmic instruments, such as the Specular Microscope or Tono-Pen. These files contain raw patient eye data or instrument calibration logs (e.g., for Topcon TSwin software). A legacy use case also exists where .tsz files are skin archives for the Trillian instant messenger, which are simply ZIP files renamed.
Common Friction Points:
Ambiguity: Windows cannot distinguish between the genetic and medical formats, leading to "Unknown File" errors.
Accessibility: Tskit files require Python knowledge to unpack; Topcon files are encrypted/locked to expensive medical hardware.
Compression: Users often try to unzip them with WinRAR, which works for Trillian/Tskit but fails for proprietary Topcon data.
Convert.Guru analyzes your TSZ file, detects the exact format, and lets you read the text inside.
If you want to convert TSZ file to INI, CFG, CONF, CONFIG, JSON, XML, YAML, YML, TOML, ENV, PROPERTIES or RC, you can use tskit & Topcon TSwin or similar software from the "Genomic Data & Medical Logs" category. In the File menu, look for Save As… or Export….
To convert ZSHRC, CONF, RCFILE, GITCONFIG, RC, PLIST, BASHRC, CONFIG, PROFILE, INI, PREFS or CFG files to TSZ, try tskit & Topcon TSwin or another comparable tool in the "Genomic Data & Medical Logs" category.
The TSZ Converter Story
The history of Convert.Guru began over 25 years ago in California with Tom Simondi’s file-format database. A former contributor to Space Shuttle development and a software pioneer of the 1980s, Simondi established a trusted resource for file type analysis that was even referenced by Microsoft Windows XP. Today, we use modern technology to process and convert thousands of file formats while continually improving our TSZ converter.